Since the beginning of this century, QSense QCM-D has been used to study viruses and virus-interaction with their immediate surrounding. Here we give examples of virus-related research where QCM-D technology has been used.
QCM-D, which is a surface-sensitive technology, has been used to explore and characterize various aspects of biological systems for more than two decades.1-3The time-resolved information of mass change at the surface can be used tostudy biomolecular interactionssuch as surface-protein, lipid-protein and protein-protein interactions, Fig. 1, and reveal, for example, interaction patterns as a function of molecules, surface and solvent conditions.
An area where such information is useful is in virus-related research. In this field, QCM-D technology has been used to shed light on several different aspects of virus behavior and interaction with the surrounding. Over the years, a vast range of viruses have been studied, for example Norovirus, Poxvirus, Rotavirus, Herpesvirus, Ebola, Hepatitis C and Zika virus.
Figure 1.Schematic illustration of how the QCM-D response can be used to reveal biomolecular interactions such as (top panel) (A) adsorption, (B) binding and (C) enzymatic action. The Δf and ΔD data (bottom panel) reflect time-resolved mass uptake and layer softness respectively and can also be used to quantify the layer thickness.
QCM-D分析是用于基础研究和应用research. The aim could for example be to gain increased knowledge and to get a fundamental understanding of virus behavior and interaction patterns in a certain context. In more applied work, the aim could for example be to develop antiviral therapies.
In the overview below, we have compiled a list of examples of virus-related publications where QCM-D technology has been used. Download the overview to learn more
Read about the key signatures in the QCM data that reveal if viscoelastic modelling should be used to extract the mass.
Viscoelasticity is a quality involving both viscous and elastic properties at the same time.
Read about what the different QCM parameters mean and which ones you should keep an eye on
QCM-sensor regeneration can be a resource efficient way of running experiments. Learn about aspects to consider if you plan to resuse ypur sensors.
Read about how QSense QCM-D analysis was used to better understand why and what affects an increased transmissibility of SARS-CoV-2
Listen to the webinar to learn more about how to combine QCM-D and Neutron reflectrometry to examine membrane biochemistry at the solid-liquid Interface
Learn about what aspects to consider when preparing your QCM samples and solvents
Read about how QSense QCM-D was used in the development of a new thermoresponsive polymer brush with antifouling properties for biomedical applications.